Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/850
Title: Frequency of vitamin K oxidoreductase complex subunit-1 (VKORC1) polymorphisms and warfarin dose management in patients with venous thromboembolism
Authors: Kabalak, Pınar Akın
Savaş, İsmail
Akar, Mehmet Nejat
Demir, Nalan
Eğin, Yonca
Keywords: maintenance
pulmonary-embolism
Turkish population
cyp4f2
anticoagulation
requirements
impact
cyp2c9
Issue Date: Sep-2018
Source: Kabalak, P. A., Savaş, İ., Akar, N., Demir, N., & Eğin, Y. (2018). Frequency of vitamin K oxidoreductase complex subunit-1 (VKORC1) polymorphisms and warfarin dose management in patients with venous thromboembolism. The pharmacogenomics journal, 18(5), 646-651.
Abstract: Warfarin works by inhibiting VKORC1, so polymorphisms of this gene modify the required drug dose. The aim of this study is to examine the relation between therapeutic weekly dose of warfarin and C1173T/G1639A polymorphism of VKORC1 in patients with VTE. Seventy-five patients with VTE were enrolled. Weekly warfarin doses and time (day) to reach therapeutic INR were evaluated retrospectively along with VKORC1–C1173T and G1639A alleles. The mean weekly warfarin dose was lower and time to reach therapeutic INR was shorter in homozygote alleles (AA and TT) (p < 0.05). The multivariate regression model was produced, R2 = 0.05% for age (p = 0.04), R2 = 6% for VKORC1 (p = 0.03), the model for estimating warfarin dose R2 = 17% (p > 0.05). In particular, patients who need overdose of warfarin or whose bleeding score is high, study of these polymorphisms can be considered.
URI: https://www.nature.com/articles/s41397-018-0037-1
https://hdl.handle.net/20.500.11851/850
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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