Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/858
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dc.contributor.authorBilgin, Esra-
dc.contributor.authorCan Demirdöğen, Birsen-
dc.contributor.authorTürkanoğlu Özçelik, Aysun-
dc.contributor.authorDemirkaya, Şeref-
dc.contributor.authorAdalı, Orhan-
dc.date.accessioned2019-03-27T07:20:24Z
dc.date.available2019-03-27T07:20:24Z
dc.date.issued2019-02-01
dc.identifier.citationBilgin, E., Can Demirdöğen, B., Türkanoğlu Özçelik, A., Demirkaya, Ş., & Adalı, O. (2019). Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population. Neurological research, 41(2), 118-124.en_US
dc.identifier.issn0161-6412
dc.identifier.urihttps://hdl.handle.net/20.500.11851/858-
dc.description.abstractObjectives: Oxidative stress is a known risk factor for the pathogenesis of atherosclerosis, the main cause of ischemic stroke. Glutathione S-transferase (GST) omega-1 and omega-2, members of phase II enzymes, play a role in the antioxidant system. The single nucleotide polymorphisms (SNPs), C419A and A424G in GST omega genes can cause a decrease in enzyme activity. The aim of this study was to investigate the possible association between these polymorphisms and ischemic stroke risk in a Turkish population. Methods: The genotypes and allele frequencies for 239 patients and 130 controls were determined by the PCR/RFLP method. No significant differences were found between patients and controls in terms of genotype and allele frequencies. Results: The frequency of the polymorphic ‘A’ allele was 0.358 in patients and 0.342 in controls for the C419A polymorphism in the GSTO1 gene. The frequency of the polymorphic ‘G’ allele for GSTO2 A424G SNP was 0.370 in patients and 0.404 in controls. The combined homozygous wild type genotype ‘CCAG’ was significantly higher in control group than in the patients. Conclusion: No significant difference was observed between the stroke patients and controls in terms of genotypes and allele distributions. Double combine haplotype CCAA was found to be protective against ischemic stroke when compare to other haplotypes. However, different genotypes of GSTO1 and GSTO2 were observed to have effects on stroke risk in subgroups of diabetics and smokers. In conclusion, the current study is the first to report this finding.en_US
dc.description.sponsorshipMiddle East Technical University Research Project Funden_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofNeurological Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSNPsen_US
dc.subjectstrokeen_US
dc.subjectischemiaen_US
dc.subjectGlutathione S transferase omega 2en_US
dc.subjectGlutathione S transferase omega 1en_US
dc.subjectGenetic polymorphismen_US
dc.titleAssociation analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish populationen_US
dc.typeArticleen_US
dcterms.dateAccepted2018-10-31
dc.departmentFaculties, Faculty of Engineering, Department of Biomedical Engineeringen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümütr_TR
dc.identifier.volume41
dc.identifier.issue2
dc.identifier.startpage118
dc.identifier.endpage124
dc.authorid0000-0002-1536-6123-
dc.identifier.wosWOS:000459561000003en_US
dc.identifier.scopus2-s2.0-85057319092en_US
dc.institutionauthorCan Demirdöğen, Birsen-
dc.identifier.pmid30417762en_US
dc.identifier.doi10.1080/01616412.2018.1544385-
dc.identifier.doi10.1080/01616412.2018.1544385-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.dept02.2. Department of Biomedical Engineering-
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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