Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8627
Title: Development of QTF-based mass-sensitive immunosensor for phenylketonuria diagnosis
Authors: Kaleli Can, Gizem
Özgüzar, Hatice Ferda
Mutlu, Mehmet
Keywords: Phenylketonuria
L-phenylalanine
Mass-sensitive biosensor
Quartz tuning fork
Plasma polymerization
Quartz Tuning Fork
Phenylalanine Dehydrogenase
Gold Electrode
Biosensor
Immobilization
Nanosheets
Platform
Issue Date: 2022
Publisher: Springer Heidelberg
Source: Kaleli-Can, G., Özgüzar, H. F., & Mutlu, M. (2022). Development of QTF-based mass-sensitive immunosensor for phenylketonuria diagnosis. Applied Physics A, 128(4), 1-8.
Abstract: In this study, a biosensor was prepared with bilayer plasma polymer films coated on a quartz tuning fork (QTF) for simple, selective, and sensitive determination of L-phenylalanine. Two-step surface modification of QTFs' prongs was performed through hexane and ethylenediamine plasma, respectively. Functionalized QTFs' surfaces were treated with glutaraldehyde at different time intervals to activate prong surfaces for antibody immobilization. Then, anti-phenylalanine was attached to the activated prongs of QTFs. The linear range for phenylalanine was found to be from 5 to 200 mu M. The sensitivity of the developed QTF-based immunosensor was obtained 0.3809 Hz/mu M. [GRAPHICS] .
URI: https://doi.org/10.1007/s00339-022-05439-7
https://hdl.handle.net/20.500.11851/8627
ISSN: 0947-8396
1432-0630
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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