Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8632
Title: Neurological Effects of SARS-CoV-2 and Neurotoxicity of Antiviral Drugs Against COVID-19
Authors: Ünlü, Büşra
Simsek, Rahime
Kose, Selinay Basak Erdemli
Yirun, Anil
Erkekoglu, Pinar
Keywords: COVID-19
neurotoxicity
SARS-CoV-2
olfactory epithelium
newborn
antiviral drugs
Nuclear Import
Adverse Events
Ivermectin
Infection
Inhibitors
Disease
Protein
Hydroxychloroquine
Chloroquine
Risk
Issue Date: 2022
Publisher: Bentham Science Publ Ltd
Source: Ünlü, B., Simsek, R., Köse, S. B. E., Yirün, A., & Erkekoglu, P. (2022). Neurological effects of SARS-CoV-2 and neurotoxicity of antiviral drugs against COVID-19. Mini Reviews in Medicinal Chemistry, 22(2), 213-231.
Abstract: Severe Acute Respiratory Syndrome (SARS) is caused by different SARS viruses. In 2020, novel coronavirus (SARS-CoV-2) led to an ongoing pandemic, known as Coronavirus Disease 2019 (COVID-19). The disease can spread among individuals through direct (via saliva, respiratory secretions, or secretion droplets) or indirect (through contaminated objects or surfaces) contact. The pandemic has spread rapidly from Asia to Europe and later to America. It continues to affect all parts of the world at an increasing rate. There have been over 92 million confirmed cases of COVID-19 by mid-January 2021. The similarity of homological sequences between SARS-CoV-2 and other SARSCoVs is high. In addition, clinical symptoms of SARS-CoV-2 and other SARS viruses show similarities. However, some COVID-19 cases show neurologic signs like headache, loss of smell, hiccups and encephalopathy. The drugs used in the palliative treatment of the disease also have some neurotoxic effects. Currently, there are approved vaccines for COVID-19. However, there is a need for specific therapeutics against COVID-19. This review will describe the neurological effects of SARS-CoV-2 and the neurotoxicity of COVID-19 drugs used in clinics. Drugs used in the treatment of COVID-19 will be evaluated by their mechanism of action and their toxicological effects.
URI: https://doi.org/10.2174/1389557521666210629100630
https://hdl.handle.net/20.500.11851/8632
ISSN: 1389-5575
1875-5607
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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