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Title: Evaluation of Lipocalin-2 and Twist expression in thyroid cancers and its relationship with epithelial mesenchymal transition
Authors: Celepli P.
Bigat, İrem
Karabulut S.
Celepli S.
Hücümenoğlu S.
Keywords: Epithelial-mesenchymal transition
Thyroid cancer
biological marker
neutrophil gelatinase associated lipocalin
transcription factor Twist
carcinoma in situ
controlled study
epithelial mesenchymal transition
human tissue
lymph node metastasis
major clinical study
nodular hyperplasia
protein expression
thyroid adenoma
thyroid cancer
thyroid follicular carcinoma
thyroid hyperplasia
thyroid medullary carcinoma
thyroid papillary carcinoma
total thyroidectomy
Issue Date: 2022
Publisher: W.B. Saunders
Source: Celepli, P., Bigat, İ., Karabulut, S., Celepli, S., & Hücümenoğlu, S. (2022). Evaluation of Lipocalin-2 and Twist expression in thyroid cancers and its relationship with epithelial mesenchymal transition. Annals of Diagnostic Pathology, 59, 151973.
Abstract: Objective: To evaluate the expressions of lipocalin-2 (LCN-2) and Twist in thyroid cancers and examine its relationship with epithelial-to-mesenchymal transition (EMT) and clinicopathological factors. Materials and methods: The expression of LCN-2 and Twist was immunohistochemically evaluated in a total of 249 cases, including 120 patients with papillary thyroid carcinomas (PTC), 34 with follicular thyroid carcinoma (FTC), 15 with medullary thyroid carcinomas (MTC), 20 with non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), 47 with follicular adenomas (FA), and 13 with nodular hyperplasia (NH). In addition, the relationship between the expression of EMT markers E-cadherin and vimentin was investigated in malignant cases. Results: A significant increase was observed in the LCN-2 and Twist expression from NH and FA to NIFTP, MTC, FTC, and PTC (p = 0.001). A high degree of LCN-2 expression was observed in the aggressive variants of PTC (p = 0.002). Twisthigh positivity was significantly higher in cases with the EMT-positive mesenchymal phenotype (p = 0.036). Conclusions: LCN-2 and Twist can be helpful diagnostic markers in the differentiation of benign and malignant thyroid nodules. Twisthigh expression supports the EMT process in thyroid cancer. LCN-2 and Twist expression may also serve as valuable predictive biomarkers in patients with thyroid cancer. In future, the determination of a LCN-2high expression in the aggressive variants of PTC may be integrated into targeted treatment strategies. © 2022 Elsevier Inc.
ISSN: 1092-9134
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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