Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8660
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dc.contributor.authorAlser, Maha-
dc.contributor.authorSalman, Hüseyin Enes-
dc.contributor.authorNaija, Azza-
dc.contributor.authorSeers, Thomas Daniel-
dc.contributor.authorKhan, Talha-
dc.contributor.authorYalcin, Huseyin Cagatay-
dc.date.accessioned2022-07-30T16:43:45Z-
dc.date.available2022-07-30T16:43:45Z-
dc.date.issued2022-
dc.identifier.citationAlser, M., Salman, H. E., Naïja, A., Seers, T. D., Khan, T., & Yalcin, H. C. (2022). Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo. Frontiers in Physiology, 499.en_US
dc.identifier.issn1664-042X-
dc.identifier.urihttps://doi.org/10.3389/fphys.2022.849603-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8660-
dc.description.abstractCollectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart's pumping power, ventricles are particularly affected by developmental abnormalities, such as flow disturbances or genomic defects. Hypoplastic Right Heart Syndrome (HRHS) is a rare disease where the right ventricle is underdeveloped. In this study, we introduce a surgical procedure performed on chick embryo, termed right atrial ligation (RAL) for disturbing hemodynamics within the right heart aiming in order to generate an animal model of HRHS. RAL is a new surgical manipulation, similar to the well-studied left atrial ligation (LAL) surgery but it induces the hemodynamic change into the right side of the heart. After inducing RAL, We utilized techniques such as Doppler ultrasound, x-ray micro-CT, histology, and computational fluid dynamics (CFD) analysis, for a comprehensive functional and structural analysis of a developing heart. Our results displayed that RAL does not induce severe flow disturbance and ventricular abnormalities consistent with clinical findings. This study allows us to better understand the hemodynamics-driven CHD development and sensitivities of ventricles under disturbed flows.en_US
dc.description.sponsorshipQatar National Research Fund (QNRF); National Priority Research Program [NPRP 10-0123-170222]; Qatar National Libraryen_US
dc.description.sponsorshipFunding This work was funded by Qatar National Research Fund (QNRF) and National Priority Research Program (Grant No. NPRP 10-0123-170222). Open Access funding was provided by the Qatar National Library.en_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Physiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcongenital heart defectsen_US
dc.subjectventricleen_US
dc.subjectchick embryoen_US
dc.subjectright atrial ligationen_US
dc.subjectultrasounden_US
dc.subjectmicro-CTen_US
dc.subjecthemodynamicsen_US
dc.subjectcomputational fluid dynamicsen_US
dc.subjectShear-Stressen_US
dc.subjectMorphogenesisen_US
dc.subjectExposureen_US
dc.subjectKlf2en_US
dc.titleBlood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryoen_US
dc.typeArticleen_US
dc.departmentFakülteler, Mühendislik Fakültesi, Makine Mühendisliği Bölümüen_US
dc.departmentFaculties, Faculty of Engineering, Department of Mechanical Engineeringen_US
dc.identifier.volume13en_US
dc.identifier.wosWOS:000795578500001en_US
dc.identifier.scopus2-s2.0-85138615936en_US
dc.institutionauthorSalman, Hüseyin Enes-
dc.identifier.pmid35492580en_US
dc.identifier.doi10.3389/fphys.2022.849603-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept02.7. Department of Mechanical Engineering-
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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