Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8711
Title: Comparison of the Kisspeptin levels in early onset preeclampsia and late-onset preeclampsia
Authors: Ibanoglu, Mujde Can
Oskovi-Kaplan, Zeynep Aslı
Ozgu-Erdinc, A. Seval
Kara, Ozgur
Sahin, Dilek
Keywords: Kisspeptin
Preeclampsia
Placenta
High-risk pregnancy
Metastasis Suppressor Gene
Placental Expression
Messenger-Rna
Pregnancy
Kiss-1
Receptor
Hypertension
Trophoblast
Hormone
Peptide
Issue Date: 2022
Publisher: Springer Heidelberg
Source: Ibanoglu, M. C., Oskovi-Kaplan, Z. A., Ozgu-Erdinc, A. S., Kara, O., & Sahin, D. (2022). Comparison of the Kisspeptin levels in early onset preeclampsia and late-onset preeclampsia. Archives of Gynecology and Obstetrics, 1-6.
Abstract: Objective Maternal Kisspeptin plays role in cell migration which is responsible for trophoblast invasion. We aimed to investigate the role of Kisspeptin as an invasion marker in the early-onset and late-onset preeclampsia cases. Study design In this case-control study, 125 patients were included: 20 patients with early-onset preeclampsia and 20 gestational-age-matched healthy controls; 45 patients with late-onset preeclampsia and 40 gestational-age-matched controls). Maternal plasma Kisspeptin concentration was measured and compared in groups regarding the presence of early-onset and late-onset preeclampsia. Results In the late-onset PE group, significantly higher maternal plasma Kisspeptin values were observed compared with the control group at > 34 weeks of gestation (68.7 +/- 93.4 pg/ml vs 68.5 +/- 57.9 pg/ml; p = 0.004). Before the 34th week of gestation, plasma Kisspeptin levels did not show a significant difference when patients with early-onset PE and gestational-age matched controls were compared (66.8 +/- 87.9 pg/ml vs 48.5 +/- 91.3 pg/ml; p = 0.56). Conclusion Plasma Kisspeptin levels were significantly higher in women with late-onset preeclampsia, while no significant difference was observed in early-onset preeclampsia when compared with healthy gestational age-matched controls. The role of Kisspeptin proteins is still not clearly defined in the pathogenesis of preeclampsia.
URI: https://doi.org/10.1007/s00404-021-06359-2
https://hdl.handle.net/20.500.11851/8711
ISSN: 0932-0067
1432-0711
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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