Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8713
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dc.contributor.authorOren, Burak-
dc.contributor.authorÖzkoyuncu Kocabaş, Dilara-
dc.date.accessioned2022-07-30T16:47:35Z-
dc.date.available2022-07-30T16:47:35Z-
dc.date.issued2022-
dc.identifier.citationOren, B., & Kocabas, D. O. (2022). Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19. Therapeutic Advances in Ophthalmology, 14, 25158414221096057.en_US
dc.identifier.issn2515-8414-
dc.identifier.urihttps://doi.org/10.1177/25158414221096057-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8713-
dc.description.abstractBackground: The ocular manifestations of the 2019 novel coronavirus disease (COVID-19) vary from acute follicular, pseudomembranous, and hemorrhagic conjunctivitis to keratoconjunctivitis with subepithelial infiltrates and dendritic lesions. Similar to other respiratory viruses, such as adenoviruses, it is thought that COVID-19 may impact the cornea. However, its impact on the cornea and anterior segment parameters are currently poorly understood. Objective: This study aims to assess the corneal endothelial cell morphology and anterior segment parameters in patients who have recovered from COVID-19. Methods: In this cross-sectional study, the COVID-19 group comprised 34 patients who had been diagnosed with and recovered from COVID-19, while the control group comprised age- and sex-matched individuals without any systemic or ocular diseases. The endothelial cell density (ECD), coefficient of variation (CV) of cell area, hexagonal cell percentage (HEX), anterior chamber depth (ACD), central corneal thickness (CCT), horizontal anterior chamber diameter (HACD), iridocorneal angle (ICA), horizontal visible iris diameter (HVID), pupillary diameter (PD), and keratometry values (K1 and K2) were analyzed for each participant. The differences in each of these between the groups were analyzed using either an independent samples t test or a Mann-Whitney U test based on the normality of the data. Results: Regarding corneal endothelial cell morphology, the ECDs for the COVID-19 and control groups were 2278.50 +/- 186.78 cells/mm(2) and 2420.15 +/- 222.25 cells/mm(2), respectively (p = 0.002). A significant increase was noted in CV values in the COVID-19 group compared with the control group (p <0.001). The HEX values for the COVID-19 and control groups were 56.26 +/- 5.75 and 61.50 +/- 3.63, respectively (p < 0.001). Regarding the anterior segment parameters, no significant differences were observed between the groups (p> 0.05). Conclusions: It was hypothesized that individuals who had recovered from COVID-19 would demonstrate a reduction in their endothelial functional preserves. A decrease in ECD and HEX and an increase in CV were observed in the individuals during their early post-recovery period from COVID-19.en_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTherapeutic Advances In Ophthalmologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectanterior segmenten_US
dc.subjectcorneal endotheliumen_US
dc.subjectcorneal topographyen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.titleAssessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19en_US
dc.typeArticleen_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentFaculties, School of Medicine, Department of Surgical Sciencesen_US
dc.identifier.volume14en_US
dc.identifier.wosWOS:000797236300001en_US
dc.identifier.scopus2-s2.0-85151733365en_US
dc.institutionauthorÖzkoyuncu Kocabaş, Dilara-
dc.identifier.pmid35574183en_US
dc.identifier.doi10.1177/25158414221096057-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.grantfulltextnone-
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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