Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8725
Title: Increased ambulatory arterial stiffness index and blood pressure load in normotensive obese patients
Authors: Efe, Fatma Kaplan
Tek, Müjgan
Keywords: Ambulatory arterial stiffness index
blood pressure load
obesity
blood pressure
Mortality
Issue Date: 2021
Publisher: Makerere Univ, Coll Health Sciences,Sch Med
Source: Efe, F. K., & Tek, M. (2021). Increased ambulatory arterial stiffness index and blood pressure load in normotensive obese patients. African health sciences, 21(3), 1185–1190. https://doi.org/10.4314/ahs.v21i3.27
Abstract: Objectives: It has been shown that blood pressure (BP) values measured in obese subjects are higher than the individuals with normal weight, even in normotensive limits. However, data concerning the Ambulatory Arterial Stiffness Index (AASI) and blood pressure load in normotensive obese subjects is lacking. This study was aimed to compare the ambulatory arterial stiffness index and blood pressure load in normotensive obese and healthy controls. Methods: One hundred normotensive obese and one hundred normal weight subjects were included in this study. All subjects underwent 24-hour ambulatory blood pressure monitoring. Ambulatory arterial stiffness index was calculated from 24-hour ambulatory blood pressure monitoring records. Ambulatory arterial stiffness index was defined as one minus the regression slope of unedited 24-h diastolic on systolic blood pressures. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) load values were calculated from 24-hour ambulatory blood pressure monitoring analysis. Results: Ambulatory arterial stiffness index of the obese subjects was significantly higher than the healthy controls (0.48 +/- 0.2 vs. 0.33 +/- 0.11, p<0.001). 24-hours systolic blood pressure and diastolic blood pressure loads were significantly higher in obese subjects. Logistic regression analysis revealed that body mass index (BMI) was an independent predictor for an abnormal ambulatory arterial stiffness index (>= 0.50) (OR: 1.137, 95% CI: 0.915-1.001, p=0.004). Conclusion: Blood pressure load and ambulatory arterial stiffness index are increased in normotensive obese patients. Moreover, body mass index is an independent predictor for an abnormal ambulatory arterial stiffness index. Our results indicate that obese subjects are at higher risk for future cardiovascular events despite normal office BP levels.
URI: https://doi.org/10.4314/ahs.v21i3.27
https://hdl.handle.net/20.500.11851/8725
ISSN: 1680-6905
1729-0503
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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