Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8731
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dc.contributor.authorEser, Miray Sekkin-
dc.contributor.authorUgur, Yesim Ulutas-
dc.contributor.authorTanacan, Atakan-
dc.contributor.authorHekimoglu, Rumeysa Gurbuz-
dc.contributor.authorÇakar, Ayşe Nur-
dc.contributor.authorBeksac, Mehmet Sinan-
dc.date.accessioned2022-07-30T16:47:38Z-
dc.date.available2022-07-30T16:47:38Z-
dc.date.issued2022-
dc.identifier.citationEser, M. S., Ugur, Y. U., Tanacan, A., Hekimoglu, R. G., Cakar, A. N., & Beksac, M. S. (2022). Evaluation of umbilical cord immune cells in pregnancies with autoimmune disorders and/or methylenetetrahydrofolate reductase polymorphisms. Journal of Perinatal Medicine.en_US
dc.identifier.issn0300-5577-
dc.identifier.issn1619-3997-
dc.identifier.urihttps://doi.org/10.1515/jpm-2021-0593-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/8731-
dc.description.abstractObjectives To evaluate umbilical cord immune cells in pregnancies with autoimmune disorders (AID) and/or methylenetetrahydrofolate reductase (MTHFR) polymorphisms. Methods Umbilical cords were obtained from seven AID women without MTHFR polymorphisms, eight with AID and MTHFR polymorphisms, nine with MTHFR polymorphisms, and eight with neither. Umbilical cords were assessed immunohistologcally by anti-CD4, anti-CD8, anti-CD14, anti-CD19, anti-CD21, and anti-CD56 antibodies in six umbilical cord zones: 1) arterial wall 2) periarterial zone 3) venous wall 4) perivenous zone 5) intervascular zone, and 6) subamniotic zone. Results AIDs and MTHFR polymorphisms had an effect on the number and composition of CD4+ cells in the venous wall. The presence of a MTHFR polymorphism may affect the number and morphology of CD4+ cells in the subamniotic zone. CD8+ cell distribution is substantially influenced by the presence of maternal risk factors. The co-existence of AID with MTHFR polymorphism has a prominent effect on the number and morphology of CD14+ cells, especially in the arterial wall. CD19+ cells were only observed in the control group in the venous wall, perivenous zone, and intervascular zone. CD21+ cells were only observed in the arterial wall of the control group and the intervascular zone of the AID group with different morphologic features. The number and morphology of CD56+ cells is prominently affected by the presence of maternal risk factors. Conclusions Umbilical cord stem cell and immune cell composition may be affected by the presence of risk factors like MTHFR polymorphisms and/or AID.en_US
dc.description.sponsorshipHacettepe University's scientific research fund [08 D07 101 014]en_US
dc.description.sponsorshipThis study was supported by Hacettepe University's scientific research fund (08 D07 101 014).en_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Perinatal Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautoimmunityen_US
dc.subjectimmune cellsen_US
dc.subjectMTHFR polymorphismsen_US
dc.subjectpregnancyen_US
dc.subjectumbilical corden_US
dc.subjectMesenchymal Stem-Cellsen_US
dc.subjectProgenitor Cellsen_US
dc.subjectPlacentaen_US
dc.subjectBlooden_US
dc.subjectFetalen_US
dc.subjectAdiposeen_US
dc.titleEvaluation of umbilical cord immune cells in pregnancies with autoimmune disorders and/or methylenetetrahydrofolate reductase polymorphismsen_US
dc.typeArticleen_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.departmentFaculties, School of Medicine, Department of Basic Medical Sciencesen_US
dc.authoridBeksac, M.Sinan/0000-0001-6362-787X-
dc.identifier.wosWOS:000773666900001en_US
dc.identifier.scopus2-s2.0-85128523729en_US
dc.institutionauthorÇakar, Ayşe Nur-
dc.identifier.pmid35344642en_US
dc.identifier.doi10.1515/jpm-2021-0593-
dc.authorscopusid57605945900-
dc.authorscopusid57604934400-
dc.authorscopusid55670176100-
dc.authorscopusid57604934500-
dc.authorscopusid35612346700-
dc.authorscopusid57022195100-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ2-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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