Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8746
Title: Headache and cognitive disturbance correlate with ganglion cell layer thickness in patients who recovered from COVID-19
Authors: Taşkıran Sağ, Aslıhan
Eroğlu, Erdal
Özülken, Kemal
Canlar, Şule
Poyraz, Barış Mustafa
Sekerlisoy, Manolya Berguzar
Mumcuoğlu, Tarkan
Keywords: COVID-19
Optical coherence tomography
Ganglion cell layer
Brain fog
Headache
COVID-19
Optical coherence tomography
Ganglion cell layer
Brain fog
Headache
Sars-Cov-2
Ace2
Issue Date: 2022
Publisher: Elsevier
Source: Taskiran-Sag, A., Eroglu, E., Ozulken, K., Canlar, S., Poyraz, B. M., Sekerlisoy, M. B., & Mumcuoglu, T. (2022). Headache and cognitive disturbance correlate with ganglion cell layer thickness in patients who recovered from COVID-19. Clinical Neurology and Neurosurgery, 217, 107263.
Abstract: Background: Retinal abnormalities are being increasingly reported in COVID-19, in addition to the well-known symptoms of this disease accounting for the neurological involvement. In this study, we aimed to investigate whether ganglion cell layer thickness (GCLT) was different in recovered COVID-19 patients compared to controls in the subacute stage and to determine whether it correlated with COVID-19-related neurological symptoms or pneumonia. Methods: This study involved 40 patients who had recovered from COVID-19 and 40 age- and sex-matched healthy controls. All the participants underwent ophthalmological examination, spectral domain optical coherence tomography and neurological examination. The clinical and biochemical properties of the patients were noted and their correlations with GCLT were sought. Results: The duration after COVID-19 infection was 113 +/- 62 (mean +/- SD) days. At this subacute stage, there was no significant difference between the GCLT measurements of the COVID-19 patients and the controls (14 +/- 4.0 mu m [median +/- IQR] vs 16 +/- 4.8 mu m, respectively). When we analyzed the relationships with neurological symptoms in the patient group, we found that patients with cognitive symptoms had lower GCLT values compared to those without (13 +/- 3 mu m vs. 16 +/- 4 mu m, respectively; p = 0.002). Patients who suffered headache during the acute infection also had lower GCLT values compared to those without (14 +/- 4 mu m vs. 18 +/- 5 mu m, respectively; p = 0.015). The GCLT values did not differ significantly with respect to anosmia, ageusia, sleep disturbances, having had COVID-19 pneumonia, or smoking status. Age, duration after COVID-19, and blood levels of thyroid stimulating hormone, glucose, vitamin D and vitamin B12 were not in correlation with GCLT in our study. Conclusion: Our findings highlight an association between GCLT values and neurological symptoms such as cognitive disturbance (brain fog) and headache in patients who had recovered after non-severe COVID-19 infection. Neuroretinal involvement by SARS-CoV2 might be linked to central neurological symptoms. The patients with lower GCLT values may benefit from close monitoring for neurological problems.
URI: https://doi.org/10.1016/j.clineuro.2022.107263
https://hdl.handle.net/20.500.11851/8746
ISSN: 0303-8467
1872-6968
Appears in Collections:Cerrahi Tıp Bilimleri Bölümü / Department of Surgical Sciences
Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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