Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/881
Title: Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles
Authors: Çiçek, Özge Senem Yücel
Hekimoğlu, Emine Rümeysa
Turğal, Mert
Atilla, Pergin
Usubütün, Alp
Çakar, Ayşe Nur
Beksaç, Mehmet Sinan
Keywords: Insulin-Like Growth Factor
Somatomedins
Fetal Development
Issue Date: Sep-2018
Publisher: W.B. Saunders Ltd.
Source: Cicek, O. S. Y., Hekimoglu, E. R., Turgal, M., Atilla, P., Cakar, A. N., Usubutun, A., & Beksac, M. S. (2018). Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles. Placenta, 69, 64-70.
Abstract: Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs. Methods: The study population included curettage material of women diagnosed as complete or partial HM as a result of histopathological and immunohistochemical examination (complete HM group, n = 8; partial HM group, n = 8) and women undergoing dilatation&curettage for unwanted pregnancies (control group, n = 8). Expression of LIF and IGF-1 among placental cell groups was evaluated immunohistochemically and given a score depending on immunostaining intensity. Results: In normal chorionic villi strong expression of LIF and IGF-1 was present. Both LIF and IGF-1 expressions were weaker in the chorionic villi of complete HMs. In complete mole decidua there was a significant decrease in glandular and endothelial IGF-1 expression along with a decrease in decidual cell LIF expression compared to normal first trimester decidua. LIF expression in extravillous trophoblasts was stronger in complete molar placentas compared to normal placentas. Discussion: LIF and IGF-1 are important regulators of trophoblast proliferation and invasion. Differential expression of LIF and IGF-1 in molar trophoblasts and chorionic villi might have a role in regulation of trophoblasts in complete moles. Decreased expression of glandular IGF-1 and decidual LIF might be related to the decidual changes during trophoblastic proliferation and invasion of decidua in complete HMs.
URI: https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0143400418306507?returnurl=null&referrer=null
https://hdl.handle.net/20.500.11851/881
ISSN: 01434004
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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