Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/884
Title: Screening of single nucleotide polymorphism in CD95 (APO-1/FAS) promoter region (G-1377A) in children with acute leukemia
Authors: Akın, Dilara Fatma
Özkan, Didem T.  
Kürekci, Emin
Akar, Nejat
258887
Keywords: CD95 polymorphism
acute myeloblastic leukemia
acute lymphoblastic leukemia
Issue Date: 2018
Publisher: Wolters Kluwer Medknow Publications
Source: Akin, D. F., Özkan, D. T., Kürekçi, E., & Akar, N. (2018). Screening of single nucleotide polymorphism in CD95 (APO-1/FAS) promoter region (G-1377A) in children with acute leukemia. The Egyptian Journal of Haematology, 43(2), 45.
Abstract: Background CD95 is a cell surface receptor involved in apoptotic signal transmission. Deregulation of this pathway results in downregulation of apoptosis and subsequent persistence of a malignant clone. A single nucleotide polymorphism resulting in guanine-to-adenine (G>A) transition in the CD95 promoter region (position −1377) is thought to reduce stimulatory protein 1 transcription factor binding and decrease CD95 expression. The purpose of this study is to examine a genetic polymorphism in the core promoter region of CD95 and to evaluate association between its frequency and clinical findings. Patients and methods G-1377A in the CD95 promoter region was genotyped by polymerase chain reaction and restriction endonuclease analysis finally were sequenced by Sanger Sequecing. Results Among 146 patients, CD95 G-1377A (rs2234767) single nucleotide polymorphism carriers frequencies have been identified as 25% (n=37) GA and AA 4% (n=6). This polymorphism of the distribution of the CD95 gene in children with acute leukemia will be a guide for future studies. Conclusion This polymorphism of the distribution of the CD95 gene in children with acute leukemia will be a guide for future studies.
URI: http://www.ehj.eg.net/article.asp?issn=1110-1067;year=2018;volume=43;issue=2;spage=45;epage=48;aulast=Akin
https://hdl.handle.net/20.500.11851/884
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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