Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/9402
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dc.contributor.authorDeveci, Erdem-
dc.contributor.authorAkbas, Fahri-
dc.contributor.authorErgün, Arif Şanlı-
dc.contributor.authorKurtulmuş, Ayse-
dc.contributor.authorKoçak, Ali Barlas-
dc.contributor.authorBoyraz, Rabia Kevser-
dc.contributor.authorKırpınar İsmet-
dc.date.accessioned2022-12-25T20:34:13Z-
dc.date.available2022-12-25T20:34:13Z-
dc.date.issued2023-
dc.identifier.issn0893-7648-
dc.identifier.issn1559-1182-
dc.identifier.urihttps://doi.org/10.1007/s12035-022-03130-9-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/9402-
dc.description.abstractWe investigated the effect of low-intensity focused ultrasound (LIFU) on gene expression related to alcohol dependence and histological effects on brain tissue. We also aimed at determining the miRNA-mRNA relationship and their pathways in alcohol dependence-induced expression changes after focused ultrasound therapy. We designed a case-control study for 100 days of observation to investigate differences in gene expression in the short-term stimulation group (STS) and long-term stimulation group (LTS) compared with the control sham group (SG). The study was performed in our Experimental Research Laboratory. 24 male high alcohol-preferring rats 63 to 79 days old, weighing 270 to 300 g, were included in the experiment. LTS received 50-day LIFU and STS received 10-day LIFU and 40-day sham stimulation, while the SG received 50-day sham stimulation. In miRNA expression analysis, it was found that LIFU caused gene expression differences in NAc. Significant differences were found between the groups for gene expression. Compared to the SG, the expression of 454 genes in the NAc region was changed in the STS while the expression of 382 genes was changed in the LTS. In the LTS, the expression of 32 genes was changed in total compared to STS. Our data suggest that LIFU targeted on NAc may assist in the treatment of alcohol dependence, especially in the long term possibly through altering gene expression. Our immunohistochemical studies verified that LIFU does not cause any tissue damage. These findings may lead to new studies in investigating the efficacy of LIFU for the treatment of alcohol dependence and also for other psychiatric disorders.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [214S249]en_US
dc.description.sponsorshipThis research is funded by a grant from the Scientific and Technological Research Council of Turkey (TUBITAK), Grant No. 214S249.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Neurobiologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLow-intensity focused ultrasound (LIFU)en_US
dc.subjectAlcohol dependencyen_US
dc.subjectNucleus accumbensen_US
dc.subjectmiRNAen_US
dc.subjectNeuromodulationen_US
dc.subjectFrontal-Cortexen_US
dc.subjectMicrornaen_US
dc.subjectEthanolen_US
dc.subjectAddictionen_US
dc.subjectCellsen_US
dc.subjectNeuromodulationen_US
dc.subjectDysregulationen_US
dc.subjectActivationen_US
dc.subjectHistoryen_US
dc.subjectDiseaseen_US
dc.titleThe Effects of Transcranial Focused Ultrasound Stimulation of Nucleus Accumbens on Neuronal Gene Expression and Brain Tissue in High Alcohol-Preferring Ratsen_US
dc.typeArticleen_US
dc.departmentESTÜen_US
dc.authoridKilic, Ozge/0000-0001-9764-343X-
dc.authoridKocak, Ali Barlas/0000-0001-8192-9249-
dc.authoridTOK, Olgu Enis/0000-0002-4899-9146-
dc.authoridErgun, Arif/0000-0002-6193-5761-
dc.authoridAYDIN, Mehmet Serif/0000-0002-6393-1465-
dc.authoridDeveci, Erdem/0000-0002-9661-8344-
dc.identifier.wosWOS:000886852300002en_US
dc.identifier.scopus2-s2.0-85142444054en_US
dc.institutionauthor[Belirlenecek]-
dc.identifier.pmid36417101en_US
dc.identifier.doi10.1007/s12035-022-03130-9-
dc.authorwosidKilic, Ozge/O-5470-2014-
dc.authorwosidTok, Olgu Enis/HGE-3451-2022-
dc.authorwosidDeveci, Erdem/L-8694-2018-
dc.authorscopusid35777650900-
dc.authorscopusid57221653534-
dc.authorscopusid35429229400-
dc.authorscopusid57197773388-
dc.authorscopusid57976955600-
dc.authorscopusid57215575877-
dc.authorscopusid55904862000-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanen_US
dc.identifier.scopusqualityQ1-
dc.identifier.trdiziniden_US]
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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