Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/1850
Title: Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma
Authors: Utku, Burkay
Dönmez, Gürhan
Erişgen, Gülriz
Akın, Şenay
Demirel, Ali Haydar
Korkusuz, Feza
Doral, Mahmut Nedim
9202
Keywords: Platelet-rich plasma
PDGF-AB
VEGF
Nonsteroidal antiinflammatory drugs
Issue Date: Feb-2017
Publisher: Scientific & Technical Research Council of Turkey
Source: Utku, B., Dönmez, G., Erişgen, G., Akin, Ş., Demirel, H. A., Korkusuz, F., & Doral, M. N. (2017). Meloxicam and diclofenac do not change VEGF and PDGF-AB serum levels of platelet-rich plasma. Turkish Journal of Medical Sciences, 47(2), 570-576. doi:10.3906/sag-1602-60
Abstract: Background/aim: Platelet-rich plasma (PRP) application has gained widespread interest for musculoskeletal injuries. Nonsteroidal antiinflammatory drugs are frequently used in sports medicine before and/or after PRP application. Our study seeks to determine whether serum levels of platelet-derived growth factor-AB (PDGF-AB) and vascular endothelial growth factor (VEGF) levels of PRP would be affected by nonsteroidal antiinflammatory drugs. Materials and methods: Two different final concentrations of diclofenac (0.5 µg mL–1 and 2.5 µg mL–1), meloxicam (0.8 µg mL–1 and 2.0 µg mL–1), and acetylsalicylic acid (final concentration 450 µm) were obtained in separate tubes with PRPs prepared from 20 healthy male volunteers. Medicine-free PRP was the control group. Growth factors were measured using ELISA. Results: PDGF-AB and VEGF serum levels did not change with diclofenac, meloxicam, or acetylsalicylic acid addition. PDGF-AB and VEGF serum levels correlated with each other. Conclusion: Diclofenac, meloxicam, and acetylsalicylic acid did not affect PDGF-AB and VEGF serum levels.
URI: https://search.trdizin.gov.tr/yayin/detay/253744
http://journals.tubitak.gov.tr/medical/issues/sag-17-47-2/sag-47-2-29-1602-60.pdf
https://hdl.handle.net/20.500.11851/1850
ISSN: 1300-0144
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Temel Tıp Bilimleri Bölümü / Department of Basic Medical Sciences
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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