Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/2740
Title: Real-Time In Vivo Control of Neural Membrane Potential by Electro-Ionic Modulation
Authors: Soybaş, Zafer
Şimşek, Sefa
Erol, F. M. Betül
Erdoğan, U. Çiya
Şimşek, Esra N.
Şahin, Büşra
Marçalı, Merve
Aydoğdu, Bahattin
Elbüken, Çağlar
Melik, Rohat
Keywords: Stimulation
trunk
activation
diaphragm
posture
block
array
pain
Issue Date: 2019
Publisher: CELL PRESS
Source: Soybaş, Z., Şimşek, S., Erol, F. M., Şimşek, E. N., Erdoğan, U. Ç., Şahin, B., ... and Melik, R. (2019). Real-Time In-Vivo Control of Neural Membrane Potential by Electro-Ionic Modulation.
Abstract: Theoretically, by controlling neural membrane potential (Vm) in vivo, motion, sensation, and behavior can be controlled. Until now, there was no available technique that can increase or decrease ion concentration in vivo in real time to change neural membrane potential. We introduce a method that we coin electro-ionic modulation (EIM), wherein ionic concentration around a nerve can be controlled in real time and in vivo. We used an interface to regulate the Ca2+ ion concentration around the sciatic nerve of a frog and thus achieved stimulation and blocking with higher resolution and lower current compared with electrical stimulation. As EIM achieves higher controllability of Vm, it has potential to replace conventional methods used for the treatment of neurological disorders and may bring a new perspective to neuromodulation techniques. © 2019 The Authors
URI: https://www.sciencedirect.com/science/article/pii/S2589004219302214?via%3Dihub
https://hdl.handle.net/20.500.11851/2740
ISSN: 2589-0042
Appears in Collections:Elektrik ve Elektronik Mühendisliği Bölümü / Department of Electrical & Electronics Engineering
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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