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Title: Nanopillared Chitosan/Gelatin Films: A Biomimetic Approach for Improved Osteogenesis
Authors: Altuntaş, Sevde
Dhaliwal, Harkiranpreet K.
Bassous, Nicole J.
Radwan, Ahmed E.
Alpaslan, Pınar
Webster, Thomas
Büyükserin, Fatih
Mansoor, Amiji
Keywords: nanopillared chitosan/gelatin film
 osteogenic differentiation
Issue Date: Sep-2019
Publisher: American Chemical Society
Source: Altuntas, S., Dhaliwal, H. K., Bassous, N. J., Radwan, A. E., Alpaslan, P., Webster, T., ... & Amiji, M. (2019). Nanopillared Chitosan/Gelatin Films: A Biomimetic Approach for Improved Osteogenesis. ACS Biomaterials Science & Engineering, 5(9), 4311-4322.
Abstract: Biomimicry strategies, inspired from natural organization of living organisms, are being widely used in the design of nanobiomaterials. Particularly, nonlithographic techniques have shown immense potential in the facile fabrication of nanostructured surfaces at large-scale production. Orthopedic biomaterials or coatings possessing extracellular matrix-like nanoscale features induce desirable interactions between the bone tissue and implant surface, also known as osseointegration. In this study, nanopillared chitosan/gelatin (C/G) films were fabricated using nanoporous anodic alumina molds, and their antibacterial properties as well as osteogenesis potential were analyzed by comparing to the flat C/G films and tissue culture polystyrene as controls. In vitro analysis of the expression of RUNX2, osteopontion, and osteocalcin genes for mesenchymal stem cells as well as osteoblast-like Saos-2 cells was found to be increased for the cells grown on nano C/G films, indicating early-stage osteogenic differentiation. Moreover, the mineralization tests (quantitative calcium analysis and alizarin red staining) showed that nanotopography significantly enhanced the mineralization capacity of both cell lines. This work may provide a new perspective of biomimetic surface topography fabrication for orthopedic implant coatings with superior osteogenic differentiation capacity and fast bone regeneration potential.
ISSN: 2373-9878
Appears in Collections:Biyomedikal Mühendisliği Bölümü / Department of Biomedical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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