Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/3226
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dc.contributor.authorCengiz, Cem-
dc.date.accessioned2019-12-30T07:24:32Z-
dc.date.available2019-12-30T07:24:32Z-
dc.date.issued2019
dc.identifier.citationCengiz, C. (2019). Serum eosinophilic cationic protein is correlated with food impaction and endoscopic severity in eosinophilic esophagitis. The Turkish Journal of Gastroenterology, 30(4), 345.en_US
dc.identifier.issn1300-4948
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/297883-
dc.identifier.urihttps://hdl.handle.net/20.500.11851/3226-
dc.identifier.urihttps://www.turkjgastroenterol.org/en/serum-eosinophilic-cationic-protein-is-correlated-with-food-impaction-and-endoscopic-severity-in-eosinophilic-esophagitis-1627099-
dc.description.abstractBackground/Aims: The aim of the present study was to analyze the diagnostic accuracy of serum eosinophilic cationic protein (ECP) for eosinophilic esophagitis (EoE) and the correlation of ECP with clinical, histopathological, laboratory, and endoscopic features of EoE. Materials and Methods: Fifteen patients with EoE and 14 healthy controls were included in the study. Demographic parameters were recorded. EoE Endoscopic Reference Score (EREFS) was calculated according to endoscopic features, and esophageal biopsies were obtained by a single experienced endoscopist in a patient group. Serum ECP levels (mu g/mL), absolute eosinophil count (U/mm(3)), and maximum peak of eosinophils/high-power field in esophageal biopsies were analyzed. Results: The median age of all participants was 33.0 (min-max: 18-46) years. There were 27 (93.1%) male patients. Serum ECP level was significantly higher in patients with EoE than in healthy volunteers (20.4 vs. 8.8, p<0.0001). According to the receiver operating characteristic (ROC) curve analysis, ECP had 80% sensitivity and 92.8% specificity to diagnose EoE with a cut-off value of 13.9 mu g/mL (area under the ROC curve 0.895; p<0.0001; 95% CI: 0.725-0.978). EREFS (p<0.0001) and the presence of food impaction (p=0.04) were significantly correlated with ECP. Conclusion: Serum ECP is an accurate non-invasive biomarker for EoE with high specificity and sensitivity. In addition, ECP is strongly correlated with EREFS and the symptom of food impaction.en_US
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEosinophilic esophagitisen_US
dc.subjecteosinophilic cationic proteinen_US
dc.subjectdiagnosisen_US
dc.titleSerum eosinophilic cationic protein is correlated with food impaction and endoscopic severity in eosinophilic esophagitisen_US
dc.typeArticleen_US
dc.departmentFaculties, School of Medicine, Department of Internal Medical Sciencesen_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümütr_TR
dc.identifier.volume30
dc.identifier.issue4
dc.identifier.startpage345
dc.identifier.endpage349
dc.identifier.wosWOS:000463369400006en_US
dc.identifier.scopus2-s2.0-85064239157en_US
dc.institutionauthorCengiz, Cem-
dc.identifier.pmid30945644en_US
dc.identifier.doi10.5152/tjg.2019.18529-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopusqualityQ3-
dc.identifier.trdizinidTWprM09EZ3pNdz09-
dc.identifier.trdizinid297883en_US
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.dept03.14. Department of Internal Medicine-
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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