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Title: The effect of environmental diesel exhaust pollution on SARS-CoV-2 infection: The mechanism of pulmonary ground glass opacity
Authors: Poyraz, Barış Mustafa
Engin, E. D.
Engin, A. B.
Engin, A.
Keywords: Alveolar macrophage
Angiotensin-converting enzyme 2
Diesel exhaust particles
Ground-glass opacity
Severe acute respiratory syndrome corona virus-2
Transforming growth factor-?1
Issue Date: 2021
Publisher: Elsevier B.V.
Abstract: Diesel exhaust particles (DEP) are the major components of atmospheric particulate matter (PM) and chronic exposure is recognized to enhance respiratory system complications. Although the spread of SARS-CoV-2 was found to be associated with the PMs, the mechanism by which exposure to DEP increases the risk of SARS-CoV-2 infection is still under discussion. However, diesel fine PM (dPM) elevate the probability of SARS-CoV-2 infection, as it coincides with the increase in the number of ACE2 receptors. Expression of ACE2 and its colocalized activator, transmembrane protease serine 2 (TMPRSS2) facilitate the entry of SARS-CoV-2 into the alveolar epithelial cells exposed to dPM. Thus, the coexistence of PM and SARS-CoV-2 in the environment augments inflammation and exacerbates lung damage. Increased TGF-?1 expression due to DEP accompanies the proliferation of the extracellular matrix. In this case, “multifocal ground-glass opacity” (GGO) in a CT scan is an indication of a cytokine storm and severe pneumonia in COVID-19. © 2021 Elsevier B.V.
ISSN: 1382-6689
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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