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Title: The effects of melatonin treatment on headache and vasomotor reactivity in patients with chronic tension-type headache
Authors: Eroğlu, Erdal
Öztürk, Bilgin
Ozon, Akcay Övünç
Koç, Güray
Karadaş, Ömer
Keywords: Chronic tension-type headache
vasomotor reactivity
Issue Date: 2021
Publisher: Wolters Kluwer Medknow Publications
Abstract: Objectives: Chronic tension-type headache (TTH) is a serious disease that disrupts quality of life. In this study, the effect of prophylactic oral melatonin treatment on headache and cerebral vasomotor reactivity (VMR) was investigated in patients diagnosed with chronic TTH per the International Classification of Headache Disorders criteria. Subjects and Methods: Twenty patients with chronic TTH and 20 healthy individuals were included in the study. The patients were administered a melatonin treatment at 3 mg/day for 12 weeks. The number of monthly painful days and pain severity were recorded with the "Visual Analog Scale" before and after the treatment. Cerebral VMR measurements were performed at baseline in the control group and in patients before and after the treatment. Results: The median number of monthly painful days was 20 (15-27) before the treatment and 10 (4-18) after the treatment; the median pain severity score was 70.00 (45-80) before the treatment and 42.50 (15-75) after the treatment. The difference was statistically significant (P = 0.001). No statistically significant difference between the VMR values was observed (P > 0.05). Conclusions: Melatonin treatment was effective in reducing the pain severity and decreasing the number of monthly painful days in patients with chronic TTH but demonstrated no effect on the cerebral VMR.
ISSN: 2636-865X
Appears in Collections:Dahili Tıp Bilimleri Bölümü / Department of Internal Medical Sciences
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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