Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.11851/8660
Title: Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo
Authors: Alser, Maha
Salman, Hüseyin Enes
Naija, Azza
Seers, Thomas Daniel
Khan, Talha
Yalcin, Huseyin Cagatay
Keywords: congenital heart defects
ventricle
chick embryo
right atrial ligation
ultrasound
micro-CT
hemodynamics
computational fluid dynamics
Shear-Stress
Morphogenesis
Exposure
Klf2
Issue Date: 2022
Publisher: Frontiers Media Sa
Source: Alser, M., Salman, H. E., Naïja, A., Seers, T. D., Khan, T., & Yalcin, H. C. (2022). Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo. Frontiers in Physiology, 499.
Abstract: Collectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart's pumping power, ventricles are particularly affected by developmental abnormalities, such as flow disturbances or genomic defects. Hypoplastic Right Heart Syndrome (HRHS) is a rare disease where the right ventricle is underdeveloped. In this study, we introduce a surgical procedure performed on chick embryo, termed right atrial ligation (RAL) for disturbing hemodynamics within the right heart aiming in order to generate an animal model of HRHS. RAL is a new surgical manipulation, similar to the well-studied left atrial ligation (LAL) surgery but it induces the hemodynamic change into the right side of the heart. After inducing RAL, We utilized techniques such as Doppler ultrasound, x-ray micro-CT, histology, and computational fluid dynamics (CFD) analysis, for a comprehensive functional and structural analysis of a developing heart. Our results displayed that RAL does not induce severe flow disturbance and ventricular abnormalities consistent with clinical findings. This study allows us to better understand the hemodynamics-driven CHD development and sensitivities of ventricles under disturbed flows.
URI: https://doi.org/10.3389/fphys.2022.849603
https://hdl.handle.net/20.500.11851/8660
ISSN: 1664-042X
Appears in Collections:Makine Mühendisliği Bölümü / Department of Mechanical Engineering
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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